We report a 39-year-old healthy woman who had an episode of sudden memory loss lasting for several hours after taking sibutramine for 4 days. Although amnesia and seizure is listed as a reported adverse event of sibutramine in the US product information, our literature search in the PubMed website database found no published reports of theses adverse events. Sibutramine (Meridia in the United States, Reductil in Europe) is approved for weight reduction and weight maintenance. Transient global amnesia after taking sibutramine: a case report. Although the etiology of accelerated long-term forgetting (ALF) and remote memory impairment (RMI) in transient epileptic amnesia (TEA) is unknown, these cases suggest frequent sleep-related seizures may contribute, and they highlight the importance of video-EEG monitoring. Memory impairment improved in both patients with successful treatment of their seizures. VEEG recorded independent bitemporal sharp waves, and 14 subclinical seizures during sleep and drowsiness. Over the course of 1 year, she had two discrete 2-h-long episodes of amnesia, with ongoing anterograde and retrograde autobiographical amnesia. Case 2 is a 50-year-old woman with known focal epilepsy also presented with memory complaints. VEEG recorded frequent interictal bitemporal sharp waves confined to sleep, and 14 subclinical seizures, also mostly during sleep. Over 18 months, she had three distinct 8-h-long episodes of confusion and disorientation with persistent anterograde and retrograde autobiographical amnesia. Case 1 is a 59-year-old woman whose presenting complaint was memory impairment. Two patients who shared similar presenting clinical features of anterograde and retrograde autobiographical amnesia typical of transient epileptic amnesia (TEA) underwent prolonged video electroencephalogram (VEEG) monitoring and were found to have sleep-activated epileptiform activity and frequent subclinical bitemporal seizures predominantly during sleep. This case adds to growing evidence for a dissociation between mechanisms subserving anterograde memory and those required to evoke remote episodic memories.įrequent sleep-related bitemporal focal seizures in transient epileptic amnesia syndrome: Evidence from ictal video-EEG.īurkholder, David B Jones, Amy L Jones, David T Fabris, Rachel R Britton, Jeffrey W Lagerlund, Terrence D So, Elson L Cascino, Gregory D Worrell, Gregory A Shin, Cheolsu St Louis, Erik K It is proposed that the autobiographical memory deficit seen in the disorder may result from the progressive erasure of cortically based memory representations. In summary, a distinct form of autobiographical amnesia, which is characterized by loss of experiential remembering of significant events, may be associated with TEA. By contrast, he performed well on tests of new learning and general knowledge and possessed good personal semantic information about his past. was unable to evoke detailed autobiographical recollections from a substantial part of his life. Tests of autobiographical memory revealed that R.G. To investigate this issue, a 68-year-old right-handed man (R.G.) who suffered from TEA and reported significant autobiographical memory problems was tested on a battery of neuropsychological tests of anterograde and remote memory. holidays, weddings, etc.) have been reported previously in patients with transient epileptic amnesia (TEA), to date there have been no detailed studies of autobiographical memory in patients with this disorder.

Manes, F Hodges, J R Graham, K S Zeman, AĪlthough problems with remembering significant events from the past (e.g. Moreover, the response to monotherapy was usually good, although the epileptic disorder was symptomatic of acquired lesions in the majority of patients.įocal autobiographical amnesia in association with transient epileptic amnesia. We outline the relevance of a detailed clinical history to recognize amnesic seizures and to avoid the more frequent misdiagnoses. We describe the clinical, electroencephalography (EEG), and neuroimaging features of 11 patients with a temporal lobe epilepsy characterized by amnesic seizures as the sole or the main symptom. Transient epileptic amnesia is a seizure disorder, usually with onset in the middle-elderly and good response to low dosages of antiepileptic drugs. Lapenta, Leonardo Brunetti, Valerio Losurdo, Anna Testani, Elisa Giannantoni, Nadia Mariagrazia Quaranta, Davide Di Lazzaro, Vincenzo Della Marca, Giacomo Transient epileptic amnesia: clinical report of a cohort of patients.

Transient epileptic amnesia treatments